abstract：BACKGROUND:Liver organoid technology holds great promises to be used in large-scale population-based drug screening and in future regenerative medicine strategies. Recently, some studies reported robust protocols for generating isogenic liver organoids using liver parenchymal and non-parenchymal cells derived from indu...

journal_title：Stem cell research & therapy

authors： Goulart E,de Caires-Junior LC,Telles-Silva KA,Araujo BHS,Kobayashi GS,Musso CM,Assoni AF,Oliveira D,Caldini E,Gerstenhaber JA,Raia S,Lelkes PI,Zatz M

更新日期：2019-08-15 00:00:00

abstract：BACKGROUND:For adipose-derived stromal cells (ASCs) to be safe for use in the clinical setting, they need to be prepared using good manufacturing practices (GMPs). Fetal bovine serum (FBS), used to expand ASCs in vitro in some human clinical trials, runs the risk of xenoimmunization and zoonotic disease transmission. T...

journal_title：Stem cell research & therapy

authors： Dessels C,Ambele MA,Pepper MS

更新日期：2019-08-14 00:00:00

abstract：BACKGROUND:Human adipose-derived stromal cells (hASCs) have been gaining increasing popularity in regenerative medicine thanks to their multipotency, ease of collection, and efficient culture. Similarly to other stromal cells, their function is particularly sensitive to the culture conditions, including the composition...

journal_title：Stem cell research & therapy

authors： Kuterbekov M,Machillot P,Baillet F,Jonas AM,Glinel K,Picart C

更新日期：2019-08-14 00:00:00

abstract：BACKGROUND:Type 1 diabetes (T1D) is an autoimmune disease resulting from the destruction of insulin-secreting islet β cells by autoreactive T cells. Non-obese diabetic (NOD) mice are the widely used animal model for human T1D. Autoimmunity in NOD mice is associated with particular major histocompatibility complex (MHC)...

journal_title：Stem cell research & therapy

authors： Su M,Lin Y,He Z,Lai L

更新日期：2019-08-06 00:00:00

abstract：BACKGROUND:iRoot BP Plus is a novel bioceramic endodontic material. Recently, it has been considered as an alternative to MTA which is the most popular scaffold cover during regenerative endodontic therapy. This study aimed to evaluate the effects of iRoot BP Plus on the osteo/odontogenic capacity of bone marrow mesenc...

journal_title：Stem cell research & therapy

authors： Lu J,Li Z,Wu X,Chen Y,Yan M,Ge X,Yu J

更新日期：2019-07-29 00:00:00

abstract：BACKGROUND:WNT and TGFβ signaling pathways play critical regulatory roles in cardiomyocyte fate determination and differentiation. MiRNAs are also known to regulate different biological processes and signaling pathways. Here, we intended to find candidate miRNAs that are involved in cardiac differentiation through regu...

journal_title：Stem cell research & therapy

authors： Kay M,Soltani BM,Aghdaei FH,Ansari H,Baharvand H

更新日期：2019-06-27 00:00:00

abstract：:Tendon injuries, as one of the most common orthopedic disorders, are the major cause of early retirement or wastage among sport horses which mainly affect the superficial digital flexor tendon (SDFT). Tendon repair is a slow process, and tendon tissue is often replaced by scar tissue. The current treatment options are...

journal_title：Stem cell research & therapy

authors： Shojaee A,Parham A

更新日期：2019-06-18 00:00:00

abstract：BACKGROUND:Hematopoietic stem cell (HSC) transplantation has been widely applied to the treatment of malignant blood diseases. However, limited number of functional HSCs hinders successful transplantation. The purpose of our current study is to develop a new and cost-efficient medium formulation that could greatly enha...

journal_title：Stem cell research & therapy

authors： Zhang Y,Shen B,Guan X,Qin M,Ren Z,Ma Y,Dai W,Ding X,Jiang Y

更新日期：2019-06-13 00:00:00

abstract：BACKGROUND:Spinal metastasis is a major challenge in patients with advanced lung cancer, but the mechanisms in the organotropism of metastasis are still unclear. Adipose-derived mesenchymal stem cells (ADSCs) exhibit cancer-promoting properties that influence the tumour microenvironment; however, there is no research o...

journal_title：Stem cell research & therapy

authors： Wang Y,Chu Y,Ren X,Xiang H,Xi Y,Ma X,Zhu K,Guo Z,Zhou C,Zhang G,Chen B

更新日期：2019-06-13 00:00:00

abstract：BACKGROUND:Non-small cell lung cancer (NSCLC) is the second most prevalent cause of cancer-related fatality. Long non-coding RNAs (lncRNAs) have been observed to exercise functions in NSCLC. Here, the current study aimed to explore the potential mechanism of lncRNA MBNL1-AS1 in NSCLC. METHODS:Microarray analysis was p...

journal_title：Stem cell research & therapy

authors： Li P,Xing W,Xu J,Yuan D,Liang G,Liu B,Ma H

更新日期：2019-05-21 00:00:00

abstract：BACKGROUND:Vascular injury is one of the most common detrimental effects of cancer radiotherapy on healthy tissues. Since the efficacy of current preventive and therapeutic strategies remains limited, the exploration of new approaches to treat radiation-induced vascular injury (RIV) is on high demands. The use of mesen...

journal_title：Stem cell research & therapy

authors： Tao X,Sun M,Chen M,Ying R,Su W,Zhang J,Xie X,Wei W,Meng X

更新日期：2019-03-13 00:00:00

abstract：BACKGROUND:Islets of Langerhans transplantation is a promising therapy for type 1 diabetes mellitus, but this technique is compromised by transplantation stresses including inflammation. In other tissues, co-transplantation with mesenchymal stem cells has been shown to reduce damage by improving anti-inflammatory and a...

journal_title：Stem cell research & therapy

authors： Laporte C,Tubbs E,Cristante J,Gauchez AS,Pesenti S,Lamarche F,Cottet-Rousselle C,Garrel C,Moisan A,Moulis JM,Fontaine E,Benhamou PY,Lablanche S

更新日期：2019-03-12 00:00:00

abstract：BACKGROUND:Mesenchymal stromal cells (MSCs) are considered potential candidates that hold great promise in the treatment of immune-related diseases. For therapeutic applications, it is necessary to isolate and expand MSCs with procedures complying with good manufacturing practice (GMP). Recent studies reported the use ...

journal_title：Stem cell research & therapy

authors： Thaweesapphithak S,Tantrawatpan C,Kheolamai P,Tantikanlayaporn D,Roytrakul S,Manochantr S

更新日期：2019-03-07 00:00:00

abstract：BACKGROUND:Optimal cell type as cell-based therapies for heart failure (HF) remains unclear. We sought to compare the safety and efficacy of direct intramyocardial transplantation of human embryonic stem cell-derived cardiomyocytes (hESC-CMs) and human induced pluripotent stem cell-derived mesenchymal stem cells (hiPSC...

journal_title：Stem cell research & therapy

authors： Liao S,Zhang Y,Ting S,Zhen Z,Luo F,Zhu Z,Jiang Y,Sun S,Lai WH,Lian Q,Tse HF

更新日期：2019-03-07 00:00:00

abstract：BACKGROUND:Bone marrow mesenchymal stem cells (BMMSCs) are suitable cell sources for dental pulp regeneration, but the mechanism of BMMSCs differentiation into odontogenic lineage remains unknown. The aim of the present study was to reveal the role of magnesium transporter protein 1 (MagT1) and MAPK pathways in the odo...

journal_title：Stem cell research & therapy

authors： Zheng JM,Kong YY,Li YY,Zhang W

更新日期：2019-01-31 00:00:00

abstract：BACKGROUND:Nanosecond pulsed electric fields (nsPEFs) can produce more significant biological effects than traditional electric fields and have thus attracted rising attention in developing medical applications based on short pulse duration and high field strength, such as effective cancer therapy. However, little is k...

journal_title：Stem cell research & therapy

authors： Ning T,Guo J,Zhang K,Li K,Zhang J,Yang Z,Ge Z

更新日期：2019-01-24 00:00:00

abstract：:Adipogenesis is essential in in vitro experimentation to assess differentiation capability of stem cells, and therefore, its accurate measurement is important. Quantitative analysis of adipogenic levels, however, is challenging and often susceptible to errors due to non-specific reading or manual estimation by observe...

journal_title：Stem cell research & therapy

authors： Yuan C,Chakraborty S,Chitta KK,Subramanian S,Lim TE,Han W,Bhanu Prakash KN,Sugii S

更新日期：2019-01-22 00:00:00

abstract：:Cognitive deficit has been identified in one third of patients affected by Duchenne Muscular Dystrophy, primarily attributed to loss of the short Dp71 dystrophin, the major brain dystrophin isoform. In this study, we investigated for the first time the Dp71 and Dp71-associated proteins cellular localization and expres...

journal_title：Stem cell research & therapy

authors： Ruggieri S,Viggiano L,Annese T,Rubolino C,Gerbino A,De Zio R,Corsi P,Tamma R,Ribatti D,Errede M,Operto F,Margari L,Resta N,Di Tommaso S,Rosati J,Trojano M,Nico B

更新日期：2019-01-15 00:00:00

abstract：BACKGROUND:Although the mononuclear cell (MNC) transplantation could theoretically induce therapeutic angiogenesis in the patients with no-option critical limb ischemia (NO-CLI), the clinical responses to this approach are inconsistent among different clinical trials. The purpose of this study was to identify the progn...

journal_title：Stem cell research & therapy

authors： Pan T,Liu H,Fang Y,Wei Z,Gu S,Fang G,Liu Y,Luo Y,Guo D,Xu X,Chen B,Jiang J,Yang J,Shi Z,Zhu T,Shi Y,Liu P,Dong Z,Fu W

更新日期：2019-01-11 00:00:00

abstract：:The original article [1] contained errors in the presentation of Figure 7. ...

journal_title：Stem cell research & therapy

authors： Gao LR,Zhang NK,Zhang Y,Chen Y,Wang L,Zhu Y,Tang HH

更新日期：2019-01-08 00:00:00

abstract：BACKGROUND:Hertwig's epithelial root sheath (HERS) is important in guiding tooth root formation by differentiating into cementoblasts through epithelial-mesenchymal transition (EMT) and inducing odontoblastic differentiation of dental papilla through epithelial-mesenchymal interaction (EMI) during the tooth root develo...

journal_title：Stem cell research & therapy

authors： Li X,Zhang S,Zhang Z,Guo W,Chen G,Tian W

更新日期：2019-01-03 00:00:00

abstract：BACKGROUND:Heart failure has become a global health problem with increasing incidences worldwide. Traditional pharmacological treatments can delay but cannot reverse the underlying disease processes. The clinical application of myocardial tissue engineering represents a promising strategy because it features cell-based...

journal_title：Stem cell research & therapy

authors： Zhang F,Xie Y,Bian Y

更新日期：2018-12-29 00:00:00

abstract：BACKGROUND:Apelin plays a key beneficial role in energy metabolism by increasing glucose uptake and insulin sensitivity; however, apelin has a short half-life because it is rapidly cleared from the circulation limiting its therapeutic benefit. The aim of this study is to create a new approach to treat type 2 diabetes b...

journal_title：Stem cell research & therapy

authors： Gao LR,Zhang NK,Zhang Y,Chen Y,Wang L,Zhu Y,Tang HH

更新日期：2018-12-07 00:00:00

abstract：BACKGROUND:Lung cancer stem cells have the ability to self-renew and are resistant to conventional chemotherapy. MicroRNAs (miRNAs) regulate and control the expression and function of many target genes; therefore, miRNA disorders are involved in the pathogenesis of human diseases, such as cancer. However, the effects o...

journal_title：Stem cell research & therapy

authors： Wang X,Meng Q,Qiao W,Ma R,Ju W,Hu J,Lu H,Cui J,Jin Z,Zhao Y,Wang Y

更新日期：2018-11-23 00:00:00

abstract：BACKGROUND:Hepatocyte transplantation has been proposed as an effective treatment for patients with acute liver failure (ALF), but its application is limited by a severe shortage of donor livers. Human pluripotent stem cells (hPSCs) have emerged as a potential cell source for regenerative medicine. Human amniotic epith...

journal_title：Stem cell research & therapy

authors： Liu QW,Liu QY,Li JY,Wei L,Ren KK,Zhang XC,Ding T,Xiao L,Zhang WJ,Wu HY,Xin HB

更新日期：2018-11-21 00:00:00

abstract：BACKGROUND:Spermatogonial stem cell transplantation (SSCT) could become a fertility restoration tool for childhood cancer survivors. However, since in mice, the colonization efficiency of transplanted spermatogonial stem cells (SSCs) is only 12%, the efficiency of the procedure needs to be improved before clinical impl...

journal_title：Stem cell research & therapy

authors： Kadam P,Ntemou E,Baert Y,Van Laere S,Van Saen D,Goossens E

更新日期：2018-11-21 00:00:00

abstract：:The use of secretome may be a new strand of cell therapy, which is equal to or even superior to the injection of live cells, called cell-free therapy. In ovarian transplantation, this approach may be a therapeutic possibility for the ovarian graft in hypoxia. We designed the present study to evaluate whether the cell-...

journal_title：Stem cell research & therapy

authors： Damous LL,de Carvalho AETS,Nakamuta JS,Shiroma ME,Louzada ACS,Soares-Jr JM,Krieger JE,Baracat EC

更新日期：2018-11-21 00:00:00

abstract：BACKGROUND:Amyotrophic lateral sclerosis (ALS) represents a devastating, progressive, heterogeneous, and the most common motor neuron (MN) disease. To date, no cure has been available for the condition. Studies with transgenic mice have yielded significant results that help us understand the underlying mechanisms of AL...

journal_title：Stem cell research & therapy

authors： Sun X,Song J,Huang H,Chen H,Qian K

更新日期：2018-11-15 00:00:00

abstract：BACKGROUND:The proangiogenic capacity of adipose tissue and its derivatives has been demonstrated in a variety of studies. The paracrine mechanism of the cellular component is considered to play a critical role in the regenerative properties of these tissues. However, cell-based therapy for clinical application has bee...

journal_title：Stem cell research & therapy

authors： Yu Z,Cai Y,Deng M,Li D,Wang X,Zheng H,Xu Y,Li W,Zhang W

更新日期：2018-11-08 00:00:00

abstract：BACKGROUND:Recent studies have demonstrated mesenchymal stem cells (MSCs) as effective mitochondrial donors with therapeutic success in multiple experimental models of human disease. MSCs obtained from different tissue sources such as bone marrow (BM), adipose (AD), dental pulp (DP), and Wharton's jelly (WJ) are routin...

journal_title：Stem cell research & therapy

authors： Paliwal S,Chaudhuri R,Agrawal A,Mohanty S

更新日期：2018-11-08 00:00:00

abstract：BACKGROUND:Severe acute pancreatitis (SAP) is an acute abdominal disease characterized by pancreatic necrosis and systemic disease. In a previous study, we showed that bone marrow-derived mesenchymal stem cells (BMSCs) can reduce SAP by secreting microRNA (miR)-9; however, the underlying mechanism remains unclear. The ...

journal_title：Stem cell research & therapy

authors： Qian D,Song G,Ma Z,Wang G,Jin L,Hu M,Song Z,Wang X

更新日期：2018-10-25 00:00:00

abstract：BACKGROUND:Efficient and sustained hematopoietic recovery after hematopoietic stem cell or bone marrow transplantation is supported by paracrine signaling from specific subpopulations of mesenchymal stromal cells (MSCs). Here, we considered whether in vitro mechanopriming of human MSCs could be administered to predicti...

journal_title：Stem cell research & therapy

authors： Liu FD,Tam K,Pishesha N,Poon Z,Van Vliet KJ

更新日期：2018-10-24 00:00:00

abstract：BACKGROUND:Bone marrow mesenchymal stem cells (BMSC) transfer has been attempted as a therapeutic strategy in experimental lung injury and fibrosis. Reduction of neutrophilic infiltration is one of the mechanisms involved in this effect. However, the mechanisms by which BMSC modulate neutrophil remains unknown. METHOD...

journal_title：Stem cell research & therapy

authors： Su X,Yang L,Yin Y,Huang J,Qiao F,Fang Y,Yu L,Wang Y,Zhou K,Wang J

更新日期：2018-09-26 00:00:00

abstract：BACKGROUND:Mesenchymal stem/stromal cells derived from chorionic villi of human term placentae (pMSCs) protect human endothelial cells from injury induced by hydrogen peroxide (H2O2). In diabetes, elevated levels of glucose (hyperglycaemia) induce H2O2 production, which causes the endothelial dysfunction that underlies...

journal_title：Stem cell research & therapy

authors： Basmaeil YS,Al Subayyil AM,Khatlani T,Bahattab E,Al-Alwan M,Abomaray FM,Kalionis B,Alshabibi MA,AlAskar AS,Abumaree MH

更新日期：2018-09-21 00:00:00

abstract：BACKGROUND:Nicotinamide adenine dinucleotide (NAD+) is a critical molecule involved in various biological functions. Poly (ADP-ribose) polymerase 1 (PARP1) and sirtuin 1 (SIRT1) affect cellular NAD+ levels and play essential roles in regulating metabolism. However, there has been little research on the effects of PARP1...

journal_title：Stem cell research & therapy

authors： Zha S,Li Z,Cao Q,Wang F,Liu F

更新日期：2018-08-23 00:00:00

abstract：BACKGROUND:Mesenchymal stromal cell (MSC)-based therapy is a promising strategy for preventing the progression of chronic kidney disease (CKD), with the potential to induce tissue regeneration. In search of the best cellular source we compared, in the rat model of adriamycin (ADR) nephropathy, the regenerative potentia...

journal_title：Stem cell research & therapy

authors： Rota C,Morigi M,Cerullo D,Introna M,Colpani O,Corna D,Capelli C,Rabelink TJ,Leuning DG,Rottoli D,Benigni A,Zoja C,Remuzzi G

更新日期：2018-08-14 00:00:00

abstract：BACKGROUND:Skin is an organ that plays an important role as a physical barrier and has many other complex functions. Skin mimetics may be useful for studying the pathophysiology of diseases in vitro and for repairing lesions in vivo. Cord blood mononuclear cells (CBMCs) have emerged as a potential cell source for regen...

journal_title：Stem cell research & therapy

authors： Kim Y,Park N,Rim YA,Nam Y,Jung H,Lee K,Ju JH

更新日期：2018-08-13 00:00:00

abstract：BACKGROUND:Adipose tissue-derived stem cells are considered to be a promising source in the field of cell therapy and regenerative medicine. In addition to direct cell replacement using adipose tissue or purified stem cells, intercellular molecule exchange by the adipose tissue complex, a vast array of bioactive secret...

journal_title：Stem cell research & therapy

authors： Bellei B,Migliano E,Tedesco M,Caputo S,Papaccio F,Lopez G,Picardo M

更新日期：2018-08-09 00:00:00

abstract：BACKGROUND:Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder that affects female fertility. However, with the lack of a corresponding research model, the pathology mechanism of PCOS is poorly understood. Induced pluripotent stem cell (iPSC) technology has been recognized as means to generate...

journal_title：Stem cell research & therapy

authors： Min Z,Gao Q,Zhen X,Fan Y,Tan T,Li R,Zhao Y,Yu Y

更新日期：2018-08-09 00:00:00

abstract：BACKGROUND:Autologous grafting, despite some disadvantages, is still considered the gold standard for reconstruction of maxillofacial bone defects. The aim of this study was to evaluate bone regeneration using bone marrow-derived mesenchymal stromal cells (MSCs) in a clinical trial, a less invasive approach than autolo...

journal_title：Stem cell research & therapy

authors： Gjerde C,Mustafa K,Hellem S,Rojewski M,Gjengedal H,Yassin MA,Feng X,Skaale S,Berge T,Rosen A,Shi XQ,Ahmed AB,Gjertsen BT,Schrezenmeier H,Layrolle P

更新日期：2018-08-09 00:00:00